Investigates how inflammatory pathways within the periodontal microenvironment drive tissue destruction, building on pioneering discoveries of a fibrin-neutrophil axis and advancing translational insight into oral immune regulation at HSDM.

He has made key contributions to our understanding of adaptive immune responses against pathogens and tumors through the use of cutting-edge in vivo imaging, single-cell technologies, and advanced animal models. His work reveals important insights into immune cell dynamics and the regulation of protective and pathological immune responses.

She has a strong interest in human microbe-specific CD4⁺ T cell responses and aims to understand their contribution to chronic inflammation. Her recent work demonstrates that TCR cross-reactivity is a key modulator of microbe-reactive T cell responses in health and disease, and that fungal microbes in particular play an important role in driving inflammatory CD4⁺ T cell reactivity in patients with inflammatory bowel diseases.

He focuses on how immune responses are regulated at barrier surfaces, particularly in the intestine. His research aims to understand the cellular and molecular mechanisms that maintain immune balance in these tissues, with in particular a focus on the role of dendritic cells and intestinal stromal cells in the regulation of mucosal immune responses.

Her work aims to elucidate the microbial communities associated with periodontal diseases and how interactions between oral microorganisms and host tissues contribute to inflammation and disease progression. More broadly, her research explores the ecological dynamics of oral microbial biofilms, the relationship between oral and gut microbiomes, and how changes in these microbial communities influence both oral health and systemic conditions.